Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP)
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …

The determination of endometrial carcinoma histological subtypes, molecular subtypes, and
mutation status is critical for the diagnostic process, and directly affects patients' prognosis …

How cells control gene expression is a fundamental question. The relative contribution of
protein-level and RNA-level regulation to this process remains unclear. Here, we perform a …

Basal cell carcinoma (BCC) is the most common skin malignancy, which rarely metastasizes
but has a great ability to infiltrate and invade the surrounding tissues. One of the molecular …

Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities
that depend on the amino acid sequence surrounding the target (phospho) tyrosine residue …

Background Immune-infiltration was positively relationship with overall survival in lung
adenocarcinoma (LUAD). Nevertheless, the potential clinical value of PTGES3, especially in …

Aberrant cellular signaling pathways are a hallmark of cancer and other diseases. One of
the most important signaling mechanisms involves protein phosphorylation …

Cancer accounted for 16% of all death worldwide in 2018. Significant progress has been
made in understanding tumor occurrence, progression, diagnosis, treatment, and prognosis …

In the era of immunotherapy, the suboptimal response rate and the development of acquired
resistance among the initial beneficiaries continue to present significant challenges across …