Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …

LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase
activity and has since been shown to have multiple essential roles in mammalian biology …

Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …

Summary Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate
transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …

Microexons represent the most highly conserved class of alternative splicing, yet their
functions are poorly understood. Here, we focus on closely related neuronal microexons …

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

Significance: Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of
human pathologies, in particular cancer. Histone acetylation balance obtained through …

LSD1 was the first histone demethylase identified by Professor Shi Yang and his team
members in 2004. LSD1 employs FAD as its cofactor, which catalyzes the demethylation of …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful
model system to uncover fundamental mechanisms that control cellular identity during …