Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting
protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like …

Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …

A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts
multiple intracellular signalling cascades. Recent studies in three general areas have …

Autoimmune myasthenia gravis (MG) is characterized by muscle weakness caused by
antibodies directed against proteins of the neuromuscular junction. The main antigenic …

A role for polyubiquitination in the activation of inhibitor of NF‐κB (IκB) kinase (IKK) through
a proteasome‐independent mechanism was first reported in 1996, but the physiological …

Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive
immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of …

Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR)
and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B …

The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive
immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB …