Associated with the CD1d protein, KRN 7000, a potent synthetic α-galactosylceramide, is
known to activate the invariant NKT immune cells. This stimulation then leads to the …

The three main broad categories of autoimmune liver disease are autoimmune hepatitis
(AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). The …

α-GalCer is the first defined and most potent agonistic antigen of the T cell receptor of
natural killer T cells. We have prepared a series of 1, 2, 3-triazole-containing α-GalCer …

One of the major pathogenesis mechanisms of SARS-CoV-2 is its potent suppression of
innate immunity, including blocking the production of type I interferons. However, it is …

Invariant natural killer T (iNKT) cells are a subpopulation of T cells that are reactive with
glycolipids that are bound by CD1d antigen-presenting molecules. α-Galactosylceramide (α …

Background Natural killer (NK) and NK T (NKT) cells are important in innate immune
defense. Their unequivocal identification requires at least four antigens. Based on the …

Invariant NKT cells (iNKT cells) have been reported to play a role not only in innate immunity
but also to regulate several models of autoimmunity. Furthermore, iNKT cells are necessary …

CD1d-restricted NKT cells can be divided into two groups: type I NKT cells use a semi-
invariant TCR, whereas type II express a relatively diverse set of TCRs. A major subset of …

Unique types of ceramide and glycolipid architectures were obtained by means of Ugi
reactions incorporating lipidic isocyanides as surrogates of sphingolipids. The …

Gaucher disease (GD) is caused by the reduced activity of a lysosomal enzyme,
glucocerebrosidase, leading to the accumulation of glucocerebroside (GC). The relatively …