Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Delivering cancer therapeutics to tumors necessitates their escape from the surrounding
blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …

Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification
by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a …

Tissue development is orchestrated by the coordinated activities of both chemical and
physical regulators. While much attention has been given to the role that chemical regulators …