Influenza, a highly contagious respiratory tract infection, affects millions of adults and
children each year. Several high-risk populations include children, the elderly, the …

Annual seasonal influenza epidemics of variable severity result in significant morbidity and
mortality in the United States (US) and worldwide. In temperate climate countries, including …

Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and
mediates the critical “cap-snatching” step of viral RNA transcription, which is considered to …

Background Estimates of influenza disease burden are broadly useful for public health,
helping national and local authorities monitor epidemiologic trends, plan and allocate …

Background The seasonal incidence of influenza is often approximated as 5%–20%.
Methods We used 2 methods to estimate the seasonal incidence of symptomatic influenza in …

Influenza infects an estimated 9–35 million individuals each year in the United States and is
a contributing cause for between 12,000 and 56,000 deaths annually. Seasonal outbreaks …

Background In recent influenza seasons, the effectiveness of inactivated influenza vaccines
against circulating A (H3N2) virus has been lower than against A (H1N1) pdm09 and B …

Background Obesity is an independent risk factor for increased influenza mortality and is
associated with impaired memory T-cell response, resulting in increased risk of infection. In …

Accurate and reliable forecasts of seasonal epidemics of infectious disease can assist in the
design of countermeasures and increase public awareness and preparedness. This article …

Preventable diseases and late diagnosis of disease impose great clinical and economic
burden for health care systems, especially in the current juncture of rising medical …