BJ Druker, NB Lydon - The Journal of clinical investigation, 2000 - Am Soc Clin Investig
AProtein kinase targeted. A number of these molecules are broad-spectrum kinase inhibitors. BStaurosporine class represents examples of broad-spectrum kinase inhibitors …
In tumor cells from virtually all patients with chronic myelogenous leukemia, the Philadelphia chromosome, a fusion of chromosomes 9 and 22, directs the synthesis of the P210 bcr/abl …
MS Arsham, MJ Barch, HJ Lawce - 2017 - books.google.com
Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed …
The search for genetic damage in neoplastic cells now occupies a central place in cancer research. Diverse examples of such damage are in hand, and they in turn hint at …
GQ Daley, D Baltimore - Proceedings of the National …, 1988 - National Acad Sciences
The P210bcr/abl protein is associated with virtually every case of human chronic myelogenous leukemia. Unlike the related P160gag/v-abl oncogene product of Abelson …
S Wong, ON Witte - Annu. Rev. Immunol., 2004 - annualreviews.org
The twenty-first century is beginning with a sharp turn in the field of cancer therapy. Molecular targeted therapies against specific oncogenic events are now possible. The BCR …
KS Kolibaba, BJ Druker - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1997 - Elsevier
The history of tyrosine kinase oncogenes can be traced to 1911 when Peyton Rous, of the Rockefeller Institute, demonstrated that a chicken tumor could be wx transplanted using a …
BJ Druker - Advances in cancer research, 2004 - books.google.com
Imatinib as a paradigm of targeted therapies Page 10 Imatinib as a Paradigm of Targeted Therapies Brian J. Druker Howard Hughes Medical Institute, Cancer Institute, Oregon Health …
M Nieborowska-Skorska, MA Wasik… - The Journal of …, 1999 - rupress.org
Signal transducer and activator of transcription (STAT) 5 is constitutively activated in BCR/ABL-expressing cells, but the mechanisms and functional consequences of such …