HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …
individuals. Most importantly, the development and deployment of combination antiretroviral …
HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment
Nearly 30 years after the advent of antiretroviral therapy (ART), CNS opportunistic infections
remain a major cause of morbidity and mortality in HIV-positive individuals. Unknown HIV …
remain a major cause of morbidity and mortality in HIV-positive individuals. Unknown HIV …
Effect estimates in randomized trials and observational studies: comparing apples with apples
S Lodi, A Phillips, J Lundgren, R Logan… - American journal of …, 2019 - academic.oup.com
Abstract Effect estimates from randomized trials and observational studies might not be
directly comparable because of differences in study design, other than randomization, and in …
directly comparable because of differences in study design, other than randomization, and in …
CNS neurotoxicity of antiretrovirals
The development of novel antiretroviral treatments has led to a significant turning point in the
fight against HIV. Although therapy leads to virologic suppression and prolonged life …
fight against HIV. Although therapy leads to virologic suppression and prolonged life …
Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?
J Underwood, KR Robertson, A Winston - Aids, 2015 - journals.lww.com
Whilst effective antiretroviral therapy is protective against the more severe forms of HIV-
associated brain disease, there remains a large burden of clinically symptomatic cognitive …
associated brain disease, there remains a large burden of clinically symptomatic cognitive …
Mechanisms of CNS Viral Seeding by HIV+ CD14+ CD16+ Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated …
ABSTRACT HIV reservoirs persist despite antiretroviral therapy (ART) and are established
within a few days after infection. Infected myeloid cells in the central nervous system (CNS) …
within a few days after infection. Infected myeloid cells in the central nervous system (CNS) …
Neurotoxicity in the post-HAART era: caution for the antiretroviral therapeutics
A Shah, MR Gangwani, NS Chaudhari, A Glazyrin… - Neurotoxicity …, 2016 - Springer
Despite the advent of highly active antiretroviral therapy (HAART), HIV-associated
neurological disorders (HAND) remain a major challenge in human immunodeficiency virus …
neurological disorders (HAND) remain a major challenge in human immunodeficiency virus …
Beneficial and adverse effects of cART affect neurocognitive function in HIV-1 infection: balancing viral suppression against neuronal stress and injury
HIV-associated neurocognitive disorders (HAND) persist despite the successful introduction
of combination antiretroviral therapy (cART). While insufficient concentration of certain …
of combination antiretroviral therapy (cART). While insufficient concentration of certain …
Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-brain barrier integrity and function
C Huang, T Hoque, R Bendayan - Frontiers in Pharmacology, 2023 - frontiersin.org
The implementation of combined antiretroviral therapy (cART) significantly reduces the
mortality associated with human immunodeficiency virus (HIV) infection. However …
mortality associated with human immunodeficiency virus (HIV) infection. However …
Cognitive trajectories over 4 years among HIV-infected women with optimal viral suppression
Objective: To determine whether persistent viral suppression alters cognitive trajectories
among HIV-infected (HIV+) women on combination antiretroviral therapy (cART) by …
among HIV-infected (HIV+) women on combination antiretroviral therapy (cART) by …