Discovery of potential phytochemicals as inhibitors of TcdB, a major virulence factors of Clostridioides difficile

MA Alamri, MH Tariq, M Tahir ul Qamar… - Journal of …, 2023 - Taylor & Francis
Clostridioides difficile is a gram-positive bacterium which is associated with different
gastrointestinal related infections, and the numbers of cases related to it are continuously …

Exploring novel microbial metabolites and drugs for inhibiting Clostridioides difficile

AA Abouelkhair, MN Seleem - Msphere, 2024 - journals.asm.org
Clostridioides difficile is an enteric pathogen that can cause a range of illnesses from mild
diarrhea to pseudomembranous colitis and even death. This pathogen often takes …

Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State

AS Paparella, SM Cahill, BL Aboulache… - ACS Chemical …, 2022 - ACS Publications
Toxins TcdA and TcdB from Clostridioides difficile glucosylate human colon Rho GTPases.
TcdA and TcdB glucosylation of RhoGTPases results in cytoskeletal changes, causing cell …

Discovery of a novel natural product inhibitor of Clostridioides difficile with potent activity in vitro and in vivo

R Pal, MN Seleem - Plos one, 2022 - journals.plos.org
Clostridioides difficile infection is a global health threat and remains the primary cause of
hospital-acquired infections worldwide. The burgeoning incidence and severity of infections …

The Hospital Environment as a Potential Source for Clostridioides difficile Transmission Based on Spore Detection Surveys Conducted at Paediatric Oncology and …

E Lemiech-Mirowska, M Michałkiewicz… - International Journal of …, 2023 - mdpi.com
Clostridioides difficile is an anaerobic, Gram-positive bacterium widely present in the
hospital environment due to its ability to generate spores. The transfer of spores to patients …

Structure–Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B

R Cummer, F Grosjean, R Bolteau… - Journal of medicinal …, 2024 - ACS Publications
Clostridioides difficile is a bacterium that causes life-threatening intestinal infections.
Infection symptoms are mediated by a toxin secreted by the bacterium. Toxin pathogenesis …

[HTML][HTML] Expansion of a Versatile Pathogen: Clostridioides difficile

T Lucas, B Brown - Hygiene and Environmental Health Advances, 2024 - Elsevier
Clostridioides difficile is a gram positive and spore forming bacterium responsible for
significant global morbidity and mortality. There is increasing incidence of C. difficile disease …

Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells

S Sarma, CM Catella, ET San Pedro, X Xiao… - Communications …, 2023 - nature.com
Infections by Clostridioides difficile, a bacterium that targets the large intestine (colon),
impact a large number of people worldwide. Bacterial colonization is mediated by two …

[HTML][HTML] Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence …

RKR Marreddy, GA Phelps, K Churion, J Picker… - Journal of Biological …, 2024 - Elsevier
Toxins TcdA and TcdB are the main virulence factors of Clostridioides difficile, a leading
cause of hospital-acquired diarrhea. Despite their importance, there is a significant …

[HTML][HTML] Insoluble polysaccharides produced in plant cell cultures protect from Clostridioides difficile colitis

G Bernabè, I Castagliuolo, A Porzionato… - Microbiological …, 2024 - Elsevier
Clostridioides difficile infection (CDI) poses a significant health threat due to high recurrence
rates. Antimicrobial agents are commonly used to manage CDI-related diarrhoea; however …