The generation of organismal form—morphogenesis—arises from forces produced at the
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …

Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

During embryonic development, regeneration, and homeostasis, cells have to migrate and
physically integrate into the target tissues where they ultimately execute their function. While …

Multiciliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to
generate fluid flow across epithelial surfaces or turbulence to promote the transport of …

The c-Jun N-terminal kinase (JNK) regulates various important physiological processes.
Although the JNK pathway has been under intense investigation for over 20 yr, its …

Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with
familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular …

Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as
signaling molecules and environmental cues. These sensory organelles are crucial to the …

Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their
surface. To template these cilia, each MCC produces between 100-600 centrioles by a …

Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia
contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and …

Barrier epithelial organs face the constant challenge of sealing the interior body from the
external environment while simultaneously replacing the cells that contact this environment …