Biology's response to dieting: the impetus for weight regain

PS MacLean, A Bergouignan… - American Journal …, 2011 - journals.physiology.org
Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

The role for adipose tissue in weight regain after weight loss

PS MacLean, JA Higgins, ED Giles, VD Sherk… - Obesity …, 2015 - Wiley Online Library
Weight regain after weight loss is a substantial challenge in obesity therapeutics. Dieting
leads to significant adaptations in the homeostatic system that controls body weight, which …

Obesity and thyroid function

T Reinehr - Molecular and cellular endocrinology, 2010 - Elsevier
A moderate elevation of thyrotropin (TSH) concentrations, which is associated with
triiodothyronine (T3) values in or slightly above the upper normal range, is frequently found …

The defence of body weight: a physiological basis for weight regain after weight loss

P Sumithran, J Proietto - Clinical Science, 2013 - portlandpress.com
Although weight loss can usually be achieved by restricting food intake, the majority of
dieters regain weight over the long-term. In the hypothalamus, hormonal signals from the …

Advances in understanding the interrelations between leptin resistance and obesity

H Pan, J Guo, Z Su - Physiology & behavior, 2014 - Elsevier
Obesity, which has developed into a global epidemic, is a risk factor in most chronic
diseases and some forms of malignancy. The discovery of leptin in 1994 has opened a new …

[HTML][HTML] Dietary protein and exercise have additive effects on body composition during weight loss in adult women

DK Layman, E Evans, JI Baum, J Seyler… - The Journal of …, 2005 - Elsevier
This study examined the interaction of 2 diets (high protein, reduced carbohydrates vs. low
protein, high carbohydrates) with exercise on body composition and blood lipids in women …

Thyroid function in humans with morbid obesity

MA Michalaki, AG Vagenakis, AS Leonardou… - Thyroid, 2006 - liebertpub.com
Morbidly obese subjects may present with abnormal thyroid function tests but the reported
data are scarce. Therefore, we studied the thyroid parameters in 144 morbidly obese …

Biological mechanisms that promote weight regain following weight loss in obese humans

CN Ochner, DM Barrios, CD Lee, FX Pi-Sunyer - Physiology & behavior, 2013 - Elsevier
Weight loss dieting remains the treatment of choice for the vast majority of obese individuals,
despite the limited long-term success of behavioral weight loss interventions. The reasons …

The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin

LH Duntas, B Biondi - Thyroid, 2013 - liebertpub.com
Background: There is increasing evidence that changes in thyroid function are associated
with obesity, a condition associated with a chronic low-grade state of inflammation …

Mechanisms of weight regain following weight loss

ES Blomain, DA Dirhan, MA Valentino… - International …, 2013 - Wiley Online Library
Obesity is a world‐wide pandemic and its incidence is on the rise along with associated
comorbidities. Currently, there are few effective therapies to combat obesity. The use of …