Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Reactive oxygen metabolites have multifactorial effects on the regulation of cell growth and
the capacity of malignant cells to invade. Overexpression of the superoxide dismutases …

Significance: Ionizing radiation is a vital component in the oncologist's arsenal for the
treatment of cancer. Approximately 50% of all cancer patients will receive some form of …

A variety of cellular activities, including metabolism, growth, and death, are regulated and
modulated by the redox status of the environment. A biphasic effect has been demonstrated …

Selenium (Se) and manganese (Mn) are essential micronutrients that are important
elements of cell metabolism. They are involved in the composition of enzyme systems and …

Loss of function of the tumor suppressor protein p53 represents a very frequent event in
human carcinogenesis, but the molecular mechanisms linking impaired p53 activity to …

This study investigates the role of the antioxidant enzyme manganese superoxide dismutase
(MnSOD) in androgen-independent human prostate cancer (PC-3) cells' growth rate in vitro …

Proline oxidase (POX), localized on inner mitochondrial membranes, is encoded by a p53-
induced gene and metabolically participates in p53-induced apoptosis. Previously, we …

Significance: Cancer is the second leading cause of death in the United States. Considering
the quality of life and treatment cost, the best way to fight against cancer is to prevent or …

Reactive oxygen species (ROS) act as both signaling molecules and mediators of cell
damage in the nervous system and are implicated in the pathogenesis of neurodegenerative …