Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Sickle cell anemia (SCA)–related cardiomyopathy is characterized by diastolic dysfunction
and hyperdynamic features. Diastolic dysfunction portends early mortality in SCA. Diastolic …

Sickle cell disease is now a chronic adult illness characterized by progressive multiorgan
failure, particularly involving the brain and kidney. The etiology is multifactorial; it includes …

Introduction: Renal dysfunction is among the most common complication of sickle cell
disease (SCD), from hyposthenuria in children to progression to overt chronic kidney …

Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different
forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently …

Sickle cell disease (SCD)–associated nephropathy is a major source of morbidity and
mortality in patients because of the lack of efficacious treatments targeting renal …

A deeper pathophysiologic understanding of available mouse models of sickle cell disease
(SCD), such as the Townes model, will help improve preclinical studies. We evaluated …

Background: Sickle cell disease is an inherited red blood cell disorder that affects
approximately 100,000 people in the USA and 25 million people worldwide. Vaso-occlusion …