The thymus is an evolutionarily conserved organ that supports the development of T cells.
Not only does the thymic environment support the rearrangement and expression of diverse …

Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively
aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and …

Type I and III interferons (IFNs) are robustly induced during infections and protect cells
against viral infection. Both type I and III IFNs are also produced at low levels in the thymus …

The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

During thymic development, thymocytes adjust their TCR response based on the strength of
their reactivity to self-peptide MHC complexes. This tuning process allows thymocytes with a …

Abstract Development of a comprehensive regulatory T (T reg) cell compartment in the
thymus is required to maintain immune homeostasis and prevent autoimmunity. In this study …

The activation of thymic B cells is critical for their licensing as antigen presenting cells and
resulting ability to mediate T cell central tolerance. The processes leading to licensing are …

The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best
identified by the expression of the transcription factor FOXP3. The development of thymus …

The thymus is home to a significant number of resident B cells which possess several
unique characteristics regarding their origin, phenotype and function. Evidence shows that …

The opposing roles of innate and adaptive immune cells in suppressing or supporting
cancer initiation, progression, metastasis and response to therapy has been long debated …