Cadherins are the principal adhesion proteins at intercellular junctions and function as the
biochemical Velcro that binds cells together. Besides this mechanical function, cadherin …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

Classical cadherin cell-cell adhesion proteins play key morphogenetic roles during
development and are essential for maintaining tissue integrity in multicellular organisms …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Classical cadherin Ca2+-dependent cell–cell adhesion proteins play key roles in
embryogenesis and in maintaining tissue integrity. Cadherins mediate robust adhesion by …

Several mechanisms have been proposed to explain the E-cadherin dysfunction in cancer,
including genetic and epigenetic alterations. Nevertheless, a significant number of human …

During development and in adult physiology, living tissues are continuously subjected to
mechanical stresses originating either from cellular processes intrinsic to the tissue or from …

Cells in epithelial tissues utilize homotypic E-cadherin interaction-mediated adhesions to
both physically adhere to each other and sense the physical properties of their …

Cell adhesion proteins play critical roles in positioning cells during development,
segregating cells into distinct tissue compartments and in maintaining tissue integrity. The …

Graphical Abstract Adhesion GPCRs as mechanosensors. Different aGPCR homologs and
their cognate ligands have been described in settings, which suggest that they function in a …