Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods
of regeneration, degeneration, and rest throughout adult life in mammals. The crucial …

Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …

Human prenatal skin is populated by innate immune cells, including macrophages, but
whether they act solely in immunity or have additional functions in morphogenesis is …

Dermal fibroblasts exhibit considerable heterogeneity during homeostasis and in response
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …

Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling
niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair …

Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident
population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle …

The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a
variety of hair follicle stem cells. The last decade has witnessed the emergence of the …

The dermal sheath (DS) is a population of mesenchyme-derived skin cells with emerging
importance for skin homeostasis. The DS includes hair follicle dermal stem cells, which …

The nail unit and hair follicle are both hard keratin-producing organs that share various
biological features. In this study, we used digital spatial profiling and single-cell RNA …