Simple Summary Anti-cancer treatments induced an increase in the childhood cancer
survival rate. However, they are responsible for several long-term side effects in childhood …

Bisphosphonates are widely used for the prevention and treatment of osteoporosis in
adulthood. In the last years, bisphosphonates have been increasingly used in pediatric …

Although substantial increases in survival rates among children diagnosed with cancer have
been observed in recent decades, survivors are at risk of developing therapy-related chronic …

Glucocorticoids (GCs) are widely used in the treatment of childhood acute lymphoblastic
leukemia (ALL), but their long-term use is also associated with bone-related morbidities …

The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable
to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity …

As chemotherapy and other sophisticated treatment strategies evolve and the number of
survivors of long-term childhood cancer grows, the long-term complications of treatment and …

Cancer progression is often paralleled by a decline in bone mass, raising risk of fracture.
Concerns persist regarding anabolic interventions for skeletal protection, as these may …

Maximizing accumulation of bone mass during childhood and adolescence is essential to
attaining optimal peak bone mass. Childhood cancer survivors (CCS) have lower bone …

Background Pediatric cancer survivors are at increased risk of developing low bone mineral
density (BMD) due to cancer treatment. This study assessed the yield of screening for low …

High-dose therapy and hematopoietic stem cell transplantation (HSCT) have been shown to
improve survival rates in high-risk neuroblastoma (HR-NBL), but may cause adverse effects …