[HTML][HTML] Common stemness regulators of embryonic and cancer stem cells
C Hadjimichael, K Chanoumidou… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
Desperately seeking microRNA targets
M Thomas, J Lieberman, A Lal - Nature structural & molecular biology, 2010 - nature.com
MicroRNAs (miRNAs) suppress gene expression by inhibiting translation, promoting mRNA
decay or both. Each miRNA may regulate hundreds of genes to control the cell's response to …
decay or both. Each miRNA may regulate hundreds of genes to control the cell's response to …
Blood exosomes endowed with magnetic and targeting properties for cancer therapy
Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously
by mammalian cells. Clinical applications for exosomes remain a challenge because of their …
by mammalian cells. Clinical applications for exosomes remain a challenge because of their …
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs
E Londin, P Loher, AG Telonis… - Proceedings of the …, 2015 - National Acad Sciences
Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …
miRNAs in animal genomes remains a vexing question. Here, we report findings from …
N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential
D Yang, J Qiao, G Wang, Y Lan, G Li, X Guo… - Nucleic acids …, 2018 - academic.oup.com
Previous studies have revealed the critical roles of N 6-methyladenosine (m6A) modification
of mRNA in embryonic stem cells (ESCs), but the biological function of m6A in large …
of mRNA in embryonic stem cells (ESCs), but the biological function of m6A in large …
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
Y Tay, J Zhang, AM Thomson, B Lim, I Rigoutsos - Nature, 2008 - nature.com
MicroRNAs (miRNAs) are short RNAs that direct messenger RNA degradation or disrupt
mRNA translation in a sequence-dependent manner,,,,,,. For more than a decade, attempts …
mRNA translation in a sequence-dependent manner,,,,,,. For more than a decade, attempts …
[HTML][HTML] Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical
for self-renewal maintenance. However, it remains unclear whether these networks …
for self-renewal maintenance. However, it remains unclear whether these networks …
[HTML][HTML] MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
N Xu, T Papagiannakopoulos, G Pan, JA Thomson… - Cell, 2009 - cell.com
MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an
important role in many developmental processes. We report here that expression of …
important role in many developmental processes. We report here that expression of …
Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
Background Cell-derived microvesicles (MVs) have been described as a new mechanism of
cell-to-cell communication. MVs after internalization within target cells may deliver genetic …
cell-to-cell communication. MVs after internalization within target cells may deliver genetic …
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
When embryonic stem cells (ESCs) differentiate, they must both silence the ESC self-
renewal program and activate new tissue-specific programs. In the absence of DGCR8 …
renewal program and activate new tissue-specific programs. In the absence of DGCR8 …