N-Propargylamines are one of the most useful and versatile building blocks in organic
synthesis that are successfully transformed into many significant N-heterocycles. Due to high …

Privileged structures have been widely used as effective templates for drug discovery. While
benzo‐1, 4‐diazepine constitutes the first historical example of such a structure, the 1, 3 …

Synthesis, structure elucidation and anticancer activities of novel fused 1, 2, 4-triazine aryl
derivatives containing the ethoxycarbonyl (6–10) and carbohydrazide formations (11–15) …

A series of 15 pyrido-imidazo-1, 3-diazepin-5-ones and pyrido-1, 3-diazepine-2, 5-diones
were synthesized and their anticancer activities were evaluated. Among tested compounds …

Pyrrolo [1, 2-b][1, 2, 5] benzothiadiazepine 5, 5-dioxides (PBTDs) induced apoptosis in
human BCR-ABL-expressing leukemia cells. The apoptotic activity was also observed in …

We have reported a one-pot two-step methodology for the synthesis of highly condensed
heterocycles, pyrrolo [1, 2-a][1, 4] benzodiazepines, by a modified Pictet–Spengler reaction …

A series of 20 optically pure 3, 4-dihydro-5 H-pyrido [1′, 2′: 1, 2] imidazo [4, 5-d][1, 3]
diazepin-5-ones which form a new family of azaheterocycle-fused [1, 3] diazepines were …

We herein report the synthesis, biological activity and preliminary structure–activity
relationships of a series of diaryl 1, 3 diazepines. These compounds were able to inhibit the …

The synthesis of novel pyrrolo [1, 2-c][1, 3] benzodiazepine and pyrrolo [3, 2-c]-[1]
benzazepine ring systems from (2-aminophenyl)(1H-pyrrol-2-yl) methanone and 2-[(1H …

Tricyclic compounds are sometimes considered as synonima of drugs healing central
nervous system pathologies, although there are some well known examples of tricyclic …