Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Tyrosine kinases were first discovered as the protein products of viral oncogenes. We now
know that this large family of metazoan enzymes includes nearly one hundred structurally …

Small molecule inhibitors of Bruton's tyrosine kinase (BTK) have been approved for the
treatment of multiple B-cell malignancies and are being evaluated for autoimmune and …

Multiple layers of regulation modulate the activity and localization of protein kinases.
However, many details of kinase regulation remain incompletely understood. Here, we apply …

Bruton's tyrosine kinase (Btk) is critical for B cell proliferation and activation, and the
development of Btk inhibitors is a vigorously pursued strategy for the treatment of various B …

Bruton's tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including
leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in …

Within eukaryotic cells, biochemical reactions need to be organized on the surface of
membrane compartments that use distinct lipid constituents to dynamically modulate the …

The Nef protein produced by the viruses HIV-1 and SIV drives efficient viral replication
partially by inducing constitutive activation of host cell tyrosine kinases, including members …

Colorectal cancer (CRC) is the fourth cause of death from cancer worldwide mainly due to
the high incidence of drug‐resistance. During a screen for new actionable targets in drug …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the loss of
adaptive immune tolerance to nucleic acid-containing antigens. The resulting …