[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
[HTML][HTML] Challenges and developments in universal vaccine design against SARS-CoV-2 variants
F Zhao, X Zai, Z Zhang, J Xu, W Chen - npj Vaccines, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had
become a global concern because of its unexpectedly high pathogenicity and …
become a global concern because of its unexpectedly high pathogenicity and …
[PDF][PDF] Circular RNA vaccines against SARS-CoV-2 and emerging variants
As the emerging variants of SARS-CoV-2 continue to drive the worldwide pandemic, there is
a constant demand for vaccines that offer more effective and broad-spectrum protection …
a constant demand for vaccines that offer more effective and broad-spectrum protection …
Efficacy of mRNA-1273 and Novavax ancestral or BA. 1 spike booster vaccines against SARS-CoV-2 BA. 5 infection in nonhuman primates
Omicron SARS-CoV-2 variants escape vaccine-induced neutralizing antibodies and cause
nearly all current COVID-19 cases. Here, we compared the efficacy of three booster …
nearly all current COVID-19 cases. Here, we compared the efficacy of three booster …
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection
NK Routhu, S Gangadhara, L Lai… - Science …, 2022 - science.org
SARS-CoV-2 vaccines should induce broadly cross-reactive humoral and T cell responses
to protect against emerging variants of concern (VOCs). Here, we inactivated the furin …
to protect against emerging variants of concern (VOCs). Here, we inactivated the furin …
Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
T Kawai, M Ikegawa, D Ori, S Akira - Immunity, 2024 - cell.com
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …
system and are the first line of host defense against microbial pathogens by recognizing …
[HTML][HTML] Resolving adjuvant mode of action to enhance vaccine efficacy
JL Turley, EC Lavelle - Current Opinion in Immunology, 2022 - Elsevier
Highlights•Adjuvants can be incorporated into vaccines to enhance the magnitude,
functionality, breadth and durability of antigen-specific immune responses.•A deeper …
functionality, breadth and durability of antigen-specific immune responses.•A deeper …
Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines
ABSTRACT Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has caused
devastating human and economic costs. Vaccination is an important step in controlling the …
devastating human and economic costs. Vaccination is an important step in controlling the …
[HTML][HTML] DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response
Effective and safe vaccines are invaluable tools in the arsenal to fight infectious diseases.
The rapid spreading of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
The rapid spreading of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …