A review of genome‐wide transcriptomics studies in Parkinson's disease

G Borrageiro, W Haylett, S Seedat… - European Journal of …, 2018 - Wiley Online Library
Parkinson's disease (PD) is a progressive and incurable neurodegenerative disorder.
Although numerous genetic and environmental factors have been linked to the aetiology of …

[HTML][HTML] Advances in protein-protein interaction network analysis for Parkinson's disease

JE Tomkins, C Manzoni - Neurobiology of Disease, 2021 - Elsevier
Protein-protein interactions (PPIs) are a key component of the subcellular molecular
networks which enable cells to function. Due to their importance in homeostasis, alterations …

Identification of new key genes for type 1 diabetes through construction and analysis of protein–protein interaction networks based on blood and pancreatic islet …

N Safari‐Alighiarloo, M Taghizadeh… - Journal of …, 2017 - Wiley Online Library
背景1 型糖尿病(T1D) 是一种自身免疫性疾病, 其特征是胰腺β 细胞被浸润的免疫细胞所破坏.
有观点认为在T1D 的进展过程中胰岛β 细胞与免疫细胞具有双向的协同作用 …

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

P Matak, A Matak, S Moustafa… - Proceedings of the …, 2016 - National Acad Sciences
Disrupted brain iron homeostasis is a common feature of neurodegenerative disease. To
begin to understand how neuronal iron handling might be involved, we focused on …

Midbrain dopamine neurons in Parkinson׳ s disease exhibit a dysregulated miRNA and target-gene network

CE Briggs, Y Wang, B Kong, TUW Woo, LK Iyer… - Brain research, 2015 - Elsevier
The degeneration of substantia nigra (SN) dopamine (DA) neurons in sporadic Parkinson׳ s
disease (PD) is characterized by disturbed gene expression networks. Micro (mi) RNAs are …

Adaptation of plasticity to projected maximum temperatures and across climatically defined bioregions

J Sandoval-Castillo, K Gates… - Proceedings of the …, 2020 - National Acad Sciences
Resilience to environmental stressors due to climate warming is influenced by local
adaptations, including plastic responses. The recent literature has focused on genomic …

[HTML][HTML] An androgen receptor regulated gene score is associated with epithelial to mesenchymal transition features in triple negative breast cancers

S Rajarajan, VP Snijesh, CE Anupama, MG Nair… - Translational …, 2023 - Elsevier
Background Androgen receptor (AR) is considered a marker of better prognosis in hormone
receptor positive breast cancers (BC), however, its role in triple negative breast cancer …

Granulation of protein–protein interaction networks in Pythagorean fuzzy soft environment

HS Nawaz, M Akram - Journal of Applied Mathematics and Computing, 2023 - Springer
Pythagorean fuzzy soft set theory is very effective to simultaneously depict the parameter-
dependent uncertainty and the uncertainty of belongingness in the entities of a system. The …

[HTML][HTML] Gene co-expression network analysis for identifying genetic markers in Parkinson's disease-a three-way comparative approach

G George, S Singh, SB Lokappa, J Varkey - Genomics, 2019 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder involving progressive
deterioration of dopaminergic neurons. Although few genetic markers for familial PD are …

[HTML][HTML] Construction and analysis of protein-protein interaction network of heroin use disorder

SJ Chen, DL Liao, CH Chen, TY Wang, KC Chen - Scientific reports, 2019 - nature.com
Heroin use disorder (HUD) is a complex disease resulting from interactions among genetic
and other factors (eg, environmental factors). The mechanism of HUD development remains …