Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

Pragnancy has commonly been viewed as a cooperative interaction between a mother and
her fetus. The effects of natural selection on genes expressed in fetuses, however, may be …

Background There is an inherited maternal predisposition to preeclampsia. Whether there is
a paternal component, however, is not known. Methods We used records of the Utah …

Murine embryos that inherit a nonfunctional insulin-like growth factor-II/cation-independent
mannose 6-phosphate receptor (Igf2r) gene from their fathers are viable and develop …

Tumors of mesenchymal and epithelial origin produce IGF-2, which activates pathways in
the tumors. In a minority of patients, the tumors (hepatomas, fibromas, and fibrosarcomas are …

Wilms' tumour, or nephroblastoma, is a common childhood tumour that is intimately linked to
early kidney development and is often associated with persistent embryonic renal tissue and …

▪ Abstract A handful of autosomal genes in the mammalian genome are inherited in a silent
state from one of the two parents, and in a fully active form from the other, thereby rendering …

Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic
expression. This parent-of-origin dependent phenomenon is a notable exception to the laws …

▪ Abstract The kinship theory of genomic imprinting proposes that parent-specific gene
expression evolves at a locus because a gene's level of expression in one individual has …

Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have
been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using …