The splicing of transfer RNA (tRNA) introns is a critical step of tRNA maturation, for intron‐
containing tRNAs. In eukaryotes, tRNA splicing is a multi‐step process that relies on several …

Simple Summary This review explores various inherited neurological conditions found in
dogs, which can be present from birth or develop later in life. Researchers use two main …

The branch point sequence is a cis-acting intronic motif required for mRNA splicing. Despite
their functional importance, branch point sequences are not routinely annotated. Here we …

Background Chronic obstructive pulmonary disease (COPD) is one of the world's leading
causes of death and a major chronic disease, highly prevalent in the aging population …

Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing
endonuclease TSEN in complex with the RNA kinase CLP1. Mutations in TSEN/CLP1 occur …

Pontocerebellar hypoplasia type 2a (PCH2a) is an ultra-rare, autosomal recessive pediatric
disorder with limited treatment options. Its anatomical hallmark is hypoplasia of the …

Background Shaking puppy syndrome is commonly attributed to abnormal myelination of the
central nervous system. Hypothesis/Objectives To report the long‐term clinical course and …

Two 9‐week‐old female littermate German Shepherd puppies showed severe high‐
frequency low‐amplitude trembling that worsened with movement. The white matter (WM) of …

Bromethalin toxicosis is an increasingly common clinical presentation in dogs that may be
fatal depending on the extent of intoxication. Antemortem diagnosis of bromethalin toxicosis …

Pontocerebellar hypoplasia type 2 a (PCH2a) is a rare, autosomal recessive neurogenetic
disorder. Affected individuals present with early and severe neurological impairment. The …