Liquid-liquid phase separation in human diseases: Functions, mechanisms and treatments
T Yue, F Zhang, Y Wei, Z Wang - Nano Today, 2024 - Elsevier
Cells are separated into functional regions by non-membrane organelles and membrane-
enclosed organelles, ensuring that various cellular activities occur in a controlled manner in …
enclosed organelles, ensuring that various cellular activities occur in a controlled manner in …
Regulatory landscape of enhancer-mediated transcriptional activation
K Kawasaki, T Fukaya - Trends in Cell Biology, 2024 - cell.com
Enhancers are noncoding regulatory elements that instruct spatial and temporal specificity of
gene transcription in response to a variety of intrinsic and extrinsic signals during …
gene transcription in response to a variety of intrinsic and extrinsic signals during …
Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription
The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to
RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the …
RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the …
Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7
The intrinsically disordered carboxy-terminal domain (CTD) of the largest subunit of RNA
Polymerase II (RNAPII) consists of multiple tandem repeats of the consensus heptapeptide …
Polymerase II (RNAPII) consists of multiple tandem repeats of the consensus heptapeptide …
Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex
RB Davis, A Supakar, AK Ranganath… - Nature …, 2024 - nature.com
Prion-like domains (PLDs) are low-complexity protein sequences enriched within nucleic
acid-binding proteins including those involved in transcription and RNA processing. PLDs of …
acid-binding proteins including those involved in transcription and RNA processing. PLDs of …
Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II
Influenza A viruses, causing seasonal epidemics and occasional pandemics, rely on
interactions with host proteins for their RNA genome transcription and replication. The viral …
interactions with host proteins for their RNA genome transcription and replication. The viral …
Conformations of a low-complexity protein in homogeneous and phase-separated frozen solutions
Solutions of the intrinsically disordered, low-complexity domain of the FUS protein (FUS-LC)
undergo liquid-liquid phase separation (LLPS) below a temperature T LLPS. To investigate …
undergo liquid-liquid phase separation (LLPS) below a temperature T LLPS. To investigate …
Clustering of RNA Polymerase II C-Terminal Domain Models upon Phosphorylation
WD Amith, VT Chen, B Dutagaci - The Journal of Physical …, 2024 - ACS Publications
RNA polymerase II (Pol II) C-terminal domain (CTD) is known to have crucial roles in
regulating transcription. CTD has also been highly recognized for undergoing phase …
regulating transcription. CTD has also been highly recognized for undergoing phase …
Disordered protein regions partner up the cBAF remodeler for a chromatin dance
M Heimhalt, AG Ladurner - Molecular Cell, 2023 - cell.com
Intrinsically disordered protein regions form condensates and mediate interactions with
factors that regulate gene activity. Patil et al. 1 decode how such regions within the …
factors that regulate gene activity. Patil et al. 1 decode how such regions within the …
Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning
A Changiarath, A Arya, VA Xenidis, J Padeken… - Faraday …, 2024 - pubs.rsc.org
Elucidating how protein sequence determines the properties of disordered proteins and their
phase-separated condensates is a great challenge in computational chemistry, biology, and …
phase-separated condensates is a great challenge in computational chemistry, biology, and …