There has been a resurgence of interest in the use of phenotypic screens in drug discovery
as an alternative to target-focused approaches. Given that oncology is currently the most …

Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and
protein expression, point to biological functions and molecular pathways being deregulated …

Glioblastoma is a lethal brain tumor that exhibits heterogeneity and resistance to therapy.
Our understanding of tumor homeostasis is limited by a lack of genetic tools to selectively …

RNA-seq is a high-throughput sequencing technology widely used for gene transcript
discovery and quantification under different biological or biomedical conditions. A …

Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks
of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription …

Epigenetic changes are frequently observed in cancer. However, their role in establishing or
sustaining the malignant state has been difficult to determine due to the lack of experimental …

Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stem cell-like
cells. BMP signaling triggers cell-cycle exit and differentiation of GBM stem cells (GSCs) …

Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant
roles in brain development, where alteration of this gene's expression significantly affects …

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which is involved in …

Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which contain a
subpopulation of tumour-propagating glioblastoma stem-like cells (GSC) thought to drive …