Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …

Expanding the palette of fluorescent dyes is vital to push the frontier of biological imaging.
Although rhodamine dyes remain the premier type of small-molecule fluorophore owing to …

Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs
within the local chromatin context. The mechanisms by which TFs navigate the nuclear …

Transcription factors show rapid and reversible binding to chromatin in living cells, and
transcription occurs in sporadic bursts, but how these phenomena are related is unknown …

The assembly of sequence-specific enhancer-binding transcription factors (TFs) at cis-
regulatory elements in the genome has long been regarded as the fundamental mechanism …

Single-molecule tracking (SMT) has emerged as the dominant technology to investigate the
dynamics of chromatin-transcription factor (TF) interactions. How long a TF needs to bind to …

Super-resolution microscopy requires that subcellular structures are labeled with bright and
photostable fluorophores, especially for live-cell imaging. Organic fluorophores may help …

Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …