Chemical synthesis of human proteoforms and application in biomedicine
H Ai, M Pan, L Liu - ACS Central Science, 2024 - ACS Publications
Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …
and the underlying mechanisms poses a major obstacle to research on human health and …
Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure
Nucleosomes are major determinants of eukaryotic genome organization and regulation.
Many studies, incorporating a diversity of experimental approaches, have been focused on …
Many studies, incorporating a diversity of experimental approaches, have been focused on …
Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1
J Düring, M Wolter, JJ Toplak, C Torres… - Nature Structural & …, 2024 - nature.com
Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
The DNA damage repair regulatory protein RNF168, a monomeric RING-type E3 ligase, has
a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of …
a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of …
Structural inscrutabilities of Histone (H2BK123) monoubiquitination: A systematic review
P Yadav, S Tanweer, M Garg, M Verma… - International Journal of …, 2024 - Elsevier
Histone H2B monoubiquitination in budding yeast is a highly conserved post-translational
modification. It is involved in normal functions of the cells like DNA Repair, RNA Pol II …
modification. It is involved in normal functions of the cells like DNA Repair, RNA Pol II …
Structural basis for the role of C-terminus acidic tail of Saccharomyces cerevisiae ubiquitin-conjugating enzyme (Rad6) in E3 ligase (Bre1) mediated recognition of …
Ubiquitination of histone H2B on chromatin is key to gene regulation. E3 ligase Bre1 and E2
Rad6 in Saccharomyces cerevisiae associate together to catalyze mono-ubiquitination at …
Rad6 in Saccharomyces cerevisiae associate together to catalyze mono-ubiquitination at …
To Ub or not to Ub: The epic dilemma of histones that regulate gene expression and epigenetic cross-talk
A Dasgupta, S Nandi, S Gupta, S Roy, C Das - Biochimica et Biophysica …, 2024 - Elsevier
A dynamic array of histone post-translational modifications (PTMs) regulate diverse cellular
processes in the eukaryotic chromatin. Among them, histone ubiquitination is particularly …
processes in the eukaryotic chromatin. Among them, histone ubiquitination is particularly …
Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168
Abstracts The DNA damage repair regulatory protein RNF168, a monomeric RING-type E3
ligase, plays a crucial role in regulating cell fate and DNA repair by specific and efficient …
ligase, plays a crucial role in regulating cell fate and DNA repair by specific and efficient …