Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering

Q Yang, J Peng, H Xiao, X Xu, Z Qian - Carbohydrate Polymers, 2022 - Elsevier
Polysaccharide hydrogels have been widely utilized in tissue engineering. They interact with
the organismal environments, modulating the cargos release and realizing of long-term …

NIR‐actuated remote activation of ferroptosis in target tumor cells through a photothermally responsive iron‐chelated biopolymer nanoplatform

C Xue, M Li, C Liu, Y Li, Y Fei, Y Hu… - Angewandte Chemie …, 2021 - Wiley Online Library
Ferroptosis is a new form of regulated cell death that shows promise for tumor treatment.
Most current ferroptosis tumor therapies are based on the intrinsic pathological features of …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …

[HTML][HTML] A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

B Yang, C Liang, D Chen, F Cheng, Y Zhang, S Wang… - Bioactive materials, 2022 - Elsevier
The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the
biological microenvironment by filling the injured cavity area and increasing neuronal …

Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks

RS Hsu, SJ Li, JH Fang, IC Lee, LA Chu, YC Lo… - Nature …, 2022 - nature.com
Traumatic brain injury causes inflammation and glial scarring that impede brain tissue
repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here …

Macrophage polarization modulated by NF‐κB in polylactide membranes‐treated peritendinous adhesion

S Wang, M Lu, W Wang, S Yu, R Yu, C Cai, Y Li, Z Shi… - Small, 2022 - Wiley Online Library
Foreign body reactions (FBR) to implants seriously impair tissue‐implant integration and
postoperative adhesion. The macrophage, owing to its phenotypic plasticity, is a major …

Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound

M Han, E Yildiz, U Bozuyuk, A Aydin, Y Yu… - Nature …, 2024 - nature.com
Electrical stimulation is a fundamental tool in studying neural circuits, treating neurological
diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric …

Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes

R Fabbri, A Scidà, E Saracino, G Conte… - Nature …, 2024 - nature.com
Astrocytes are responsible for maintaining homoeostasis and cognitive functions through
calcium signalling, a process that is altered in brain diseases. Current bioelectronic tools are …

Immunomodulatory Biomaterials: Tailoring Surface Properties to Mitigate Foreign Body Reaction and Enhance Tissue Regeneration

H Amani, M Alipour, E Shahriari… - Advanced Healthcare …, 2024 - Wiley Online Library
The immune cells have demonstrated the ability to promote tissue repair by removing debris,
breaking down the extracellular matrix, and regulating cytokine secretion profile. If the …