Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for~ 2–4%
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …

Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The
conventional therapies used in cancer prevention/treatment suffer from low efficacy …

Background Inflammatory breast cancer (IBC), a particularly aggressive form of breast
cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted …

Introduction: Numerous clinical and pre-clinical studies have provided ample evidence
supporting that the tumor microenvironment plays a significant role during breast cancer …

Inflammatory breast cancer (IBC) is a highly aggressive form of breast cancer that displays
profound cancer stem cell (CSC) and mesenchymal features that promote rapid metastasis …

Preclinical data support a role for the IL-6/JAK2/STAT3 signaling pathway in breast cancer.
Ruxolitinib is an orally bioavailable receptor tyrosine inhibitor targeting JAK1 and JAK2. We …

Background Aberrant activation of STAT3 is frequently encountered and promotes survival,
cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin …

Background and Aims Intrahepatic cholangiocarcinoma (iCCA) and hepatocellular
carcinoma (HCC) are the most common primary liver cancers (PLCs). Differences in their …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …