Overview of growth differentiation factor 15 in metabolic syndrome

M Asrih, S Wei, TT Nguyen, HS Yi… - Journal of Cellular …, 2023 - Wiley Online Library
Growth and differentiation factor 15 (GDF15) is a member of the transforming growth factor‐β
(TGF‐β) superfamily. GDF15 has been linked with several metabolic syndrome pathologies …

Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure

HM Al‐kuraishy, AI Al‐Gareeb, A Alexiou… - Journal of …, 2022 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a chronic endocrine disorder due to the reduction of
insulin sensitivity and relative deficiency of insulin secretion. Growth differentiation factor 15 …

Growth differentiation factor 15 (GDF-15) in endocrinology

P Iglesias, RA Silvestre, JJ Díez - Endocrine, 2023 - Springer
Human growth differentiation factor 15 (GDF-15) is a widely distributed protein that has
shown to play multiple roles in both physiological and pathological conditions. In healthy …

[HTML][HTML] GDF-15 and mtDNA deletions are useful biomarkers of mitochondrial dysfunction in insulin resistance and PCOS

V Varhegyi, A Modos, D Trager, D Gerszi… - International Journal of …, 2024 - mdpi.com
There is no literature available about the growth differentiation factor-15 (GDF-15) biomarker
in combination with mitochondrial DNA (mtDNA) deletions in insulin resistance (IR), and …

GDF15 plays a critical role in insulin secretion in INS-1 cells and human pancreatic islets

MG Mohammad, R Saeed… - Experimental …, 2023 - journals.sagepub.com
Mounting evidence points to a link between growth differentiation factor-15 (GDF15)
expression and the onset and progression of diabetes mellitus. However, the exact role of …

A single-cell survey of cellular heterogeneity in human great saphenous veins

Y Sun, X Hu, K Zhang, M Rao, P Yin, R Dong - Cells, 2022 - mdpi.com
Background: The great saphenous vein (GSV) is the most commonly used conduit for
coronary arterial bypass graft. However, the status of the GSV, including metabolic …

Growth differentiation factor 15 is not modified after weight loss induced by liraglutide in South Asians and Europids with type 2 diabetes mellitus

CA Hoekx, ME Straat, MB Bizino… - Experimental …, 2024 - Wiley Online Library
Abstract Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists induce weight loss in patients
with type 2 diabetes mellitus (T2DM), but the underlying mechanism is unclear. Recently, the …

Diabetes-induced muscle wasting: molecular mechanisms and promising therapeutic targets

R Qiao, J Guo, C Zhang, S Wang, J Fang… - Critical Reviews in …, 2024 - Taylor & Francis
Diabetes has become a serious public health crisis, presenting significant challenges to
individuals worldwide. As the largest organ in the human body, skeletal muscle is a …

Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity

Q Wang, M Farhadipour, T Thijs, ER Sosoranga… - Molecular …, 2024 - Elsevier
Objective Growth differentiation factor 15 (GDF15), a stress related cytokine, was recently
identified as a novel satiety signal acting via the GFRAL receptor located in the hindbrain …

Protection of β cells against pro-inflammatory cytokine stress by the GDF15-ERBB2 signaling

S Sarkar, F Syed, BJ Webb-Robertson, JT Melchior… - medRxiv, 2023 - medrxiv.org
Aim/hypothesis Growth/differentiation factor 15 (GDF15) is a therapeutic target for a variety
of metabolic diseases, including type 1 diabetes (T1D). However, the nausea caused by …