Macrophages represent a key cellular component of the liver, and are essential for
maintaining tissue homeostasis and ensuring rapid responses to hepatic injury. Our …

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

Drug‐induced liver injury (DILI) is an important cause of acute liver failure, with limited
therapeutic options. During DILI, oncotic necrosis with concomitant release and recognition …

Control of homeostasis and rapid response to tissue damage in the liver is orchestrated by
crosstalk between resident and infiltrating inflammatory cells. A crucial role for myeloid cells …

Background: The liver has a number of functions in innate immunity. These functions
predispose the liver to innate immune-mediated liver injury when inflammation goes …

Extracellular nucleotides, including ATP, are essential regulators of liver function and serve
as danger signals that trigger inflammation upon injury. Ectonucleotidases, which are …