The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

It is well established that contracting muscles produce both reactive oxygen and nitrogen
species. Although the sources of oxidant production during exercise continue to be debated …

The ryanodine receptor (RyR) c corresponds to the sarcoplasmic reticulum (SR) Ca2+
channel (Inui et al., 1987; Imagawa et al., 1987). Its structure and function have been …

Mitochondria are an important source of reactive oxygen species (ROS) formed as a side
product of oxidative phosphorylation. The main sites of oxidant production are complex I and …

Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …

Complexities in calcium signaling in eukaryotic cells require diversity in the proteins
involved in generating these signals. In this review, we consider the ryanodine receptor …

The endothelial-derived relaxing factor, nitric oxide (NO·) has been shown to depress force
in smooth and cardiac muscles through the activation of guanylyl cyclase and an increase in …

Purpose Oxidative stress is implicit in the pathological changes associated with glaucoma.
The purpose of this study was to compare levels of oxidative stress in glial fibrillary acid …

Glaucoma is an age-related optic neuropathy involving sensitivity to ocular pressure. The
disease is now seen increasingly as one of the central nervous system, as powerful new …

The calcium dependence of ryanodine-sensitive single calcium channels was studied after
fusing with planar lipid bilayers sarcoendoplasmic reticulum vesicles isolated from excitable …