Monocyte chemoattractant protein-1 (MCP-1/CCL2) drives activation of bone remodelling and skeletal metastasis
BS Mulholland, MR Forwood, NA Morrison - Current osteoporosis reports, 2019 - Springer
Abstract Purpose of Review The purpose of this review is to explore the role of monocyte
chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone …
chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone …
A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment
L Dillemans, L De Somer, B Neerinckx… - Cellular and Molecular …, 2023 - Springer
Chemokines are pivotal players in instigation and perpetuation of synovitis through
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …
Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection
The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus
(CHIKV), highlights an urgent need for the development of therapeutic intervention …
(CHIKV), highlights an urgent need for the development of therapeutic intervention …
The monocyte-to-osteoclast transition in rheumatoid arthritis: Recent findings
N Iwamoto, A Kawakami - Frontiers in Immunology, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation
leading to joint destruction and deformity. The crucial role of osteoclasts in the bone erosion …
leading to joint destruction and deformity. The crucial role of osteoclasts in the bone erosion …
Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells
Background The peripheral blood (PB) monocyte pool contains osteoclast progenitors
(OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by …
(OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by …
Role of chemokine receptor 2 in rheumatoid arthritis: A research update
W Chen, Y Fang, H Wang, X Tan, X Zhu, Z Xu… - International …, 2023 - Elsevier
Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease
characterized by joint destruction. The C–C motif chemokine receptor 2 (CCR2) is mainly …
characterized by joint destruction. The C–C motif chemokine receptor 2 (CCR2) is mainly …
Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways
W Shang, LJ Zhao, XL Dong… - Molecular …, 2016 - spandidos-publications.com
The aim of the present study was to determine the effects of curcumin on the
osteoclastogenic potential of peripheral blood mononuclear cells (PBMCs) obtained from …
osteoclastogenic potential of peripheral blood mononuclear cells (PBMCs) obtained from …
What are the peripheral blood determinants for increased osteoclast formation in the various inflammatory diseases associated with bone loss?
TJ de Vries, I El Bakkali, T Kamradt, G Schett… - Frontiers in …, 2019 - frontiersin.org
Local priming of osteoclast precursors (OCp) has long been considered the main and
obvious pathway that takes place in the human body, where local bone lining cells and …
obvious pathway that takes place in the human body, where local bone lining cells and …
Synovial fluid and serum concentrations of inflammatory markers in rheumatoid arthritis, psoriatic arthritis and osteoarthitis: a systematic review
E Altobelli, PM Angeletti, D Piccolo… - Current rheumatology …, 2017 - ingentaconnect.com
Background: The aim of this review is to investigate systematically the presence of the most
extensively studied Synovial Fluid (SF) and/or serum markers in patients with Rheumatoid …
extensively studied Synovial Fluid (SF) and/or serum markers in patients with Rheumatoid …
Induction of osteoclast progenitors in inflammatory conditions: key to bone destruction in arthritis
The inflammatory milieu favors recruitment and activation of osteoclasts, and leads to bone
destruction as a serious complication associated with arthritis and with other inflammatory …
destruction as a serious complication associated with arthritis and with other inflammatory …