Mesenchymal stem cell-derived exosomes: applications in regenerative medicine

MD Hade, CN Suire, Z Suo - Cells, 2021 - mdpi.com
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Y Xiong, X Chu, T Yu, S Knoedler… - Advanced …, 2023 - Wiley Online Library
Diabetic wounds are characterized by drug‐resistant bacterial infections, biofilm formation,
impaired angiogenesis and perfusion, and oxidative damage to the microenvironment …

Extracellular vesicles: Emerging frontiers in wound healing

MD Hade, CN Suire, J Mossell… - Medicinal Research …, 2022 - Wiley Online Library
Extracellular vesicles are membranous particles, ranging from 30 nm to 10 µm in diameter,
which are released by nearly all cell types to aid in intercellular communication. These …

MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

Q Li, W Hu, Q Huang, J Yang, B Li, K Ma… - Signal transduction and …, 2023 - nature.com
Unhealable diabetic wounds need to be addressed with the help of newer, more efficacious
strategies. Exosomes combined with biomaterials for sustained delivery of therapeutic …

Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Y Yin, H Chen, Y Wang, L Zhang… - Journal of extracellular …, 2021 - Wiley Online Library
Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …

MiR‐141‐3p‐Functionalized Exosomes Loaded in Dissolvable Microneedle Arrays for Hypertrophic Scar Treatment

S Meng, Q Wei, S Chen, X Liu, S Cui, Q Huang, Z Chu… - Small, 2024 - Wiley Online Library
Hypertrophic scar (HS) is a common fibroproliferative disease caused by abnormal wound
healing after deep skin injury. However, the existing approaches have unsatisfactory …

Molecular pathophysiology of chronic wounds: current state and future directions

I Pastar, NC Balukoff, J Marjanovic… - Cold Spring …, 2023 - cshperspectives.cshlp.org
Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds
with multifactorial etiologies that are associated with high patient morbidity and mortality …

Extracellular vesicles from human umbilical cord mesenchymal stem cells facilitate diabetic wound healing through MiR-17-5p-mediated enhancement of …

Q Wei, Y Wang, K Ma, Q Li, B Li, W Hu, X Fu… - Stem cell reviews and …, 2022 - Springer
Endothelial dysfunction caused by persistent hyperglycemia in diabetes is responsible for
impaired angiogenesis in diabetic wounds. Extracellular vehicles (EVs) are considered …

Research advances on the damage mechanism of skin glycation and related inhibitors

W Zheng, H Li, Y Go, XH Chan, Q Huang, J Wu - Nutrients, 2022 - mdpi.com
Our skin is an organ with the largest contact area between the human body and the external
environment. Skin aging is affected directly by both endogenous factors and exogenous …

Mesenchymal stromal cell-conditioned medium for skin diseases: a systematic review

T Montero-Vilchez, Á Sierra-Sánchez… - Frontiers in cell and …, 2021 - frontiersin.org
The skin is the largest organ of the human body, and its dysfunction is related to many
diseases. There is a need to find new potential effective therapies for some skin conditions …