Alternative splicing of viral transcripts: the dark side of HBV

D Kremsdorf, B Lekbaby, P Bablon, J Sotty, J Augustin… - Gut, 2021 - gut.bmj.com
Regulation of alternative splicing is one of the most efficient mechanisms to enlarge the
proteomic diversity in eukaryotic organisms. Many viruses hijack the splicing machinery …

Virological basis for the cure of chronic hepatitis B

J Hu, J Cheng, L Tang, Z Hu, Y Luo, Y Li… - ACS infectious …, 2018 - ACS Publications
Hepatitis B virus (HBV) has infected one-third of world population, and 240 million people
are chronic carriers, to whom a curative therapy is still not available. Similar to other viruses …

Oncogenes and RNA splicing of human tumor viruses

M Ajiro, ZM Zheng - Emerging microbes & infections, 2014 - Taylor & Francis
Approximately 10.8% of human cancers are associated with infection by an oncogenic virus.
These viruses include human papillomavirus (HPV), Epstein–Barr virus (EBV), Merkel cell …

Cell type diversity in hepatitis B virus RNA splicing and its regulation

N Ito, K Nakashima, S Sun, M Ito, T Suzuki - Frontiers in microbiology, 2019 - frontiersin.org
Although RNA splicing of hepatitis B virus (HBV) is a commonly observed in livers of
hepatitis B patients as well as in the cultured cells replicating the viral genome, its biological …

Biological and clinical significance of hepatitis B virus RNA splicing: an update

D Candotti, JP Allain - Annals of Blood, 2017 - aob.amegroups.org
Hepatitis B virus (HBV) persistent infection remains a major public health issue. Long-lasting
persistence/occult carriage is associated with a strong inhibition of HBV replication and viral …

[HTML][HTML] Polypyrimidine tract binding protein (PTB) associates with intronic and exonic domains to squelch nuclear export of unspliced RNA

D Roy, JB Chowdhury, S Ghosh - FEBS letters, 2013 - Elsevier
Retention of unspliced pre-messenger RNA (pre-mRNA) in the nucleus is essential for cell
survival. Available nuclear factors must recognize and discern between diverse export …

Implications of Circulating Hepatitis B Virus RNA Levels in Assessment of Response to Antiviral Therapy

T Zhou, C Wang, A Sayeed, T Block - Current Hepatology Reports, 2018 - Springer
Abstract Purpose of Review Treatment of chronic hepatitis B infection with nucleos (t) ide
analogues induces a significant inhibition of HBV DNA titer. However, reduction of viral DNA …

Role of the DEAD-box Helicases DDX5 and DDX17 in Hepatitis B Virus RNA processing

F Chapus - 2020 - theses.hal.science
Role of the DEAD-box helicases DDX5 and DDX17 in HBV transcriptional regulation and
RNA processingChronicity of hepatitis B virus (HBV) infection hinges on the persistence of …

A Newly Identified Natural Splice Variant ASN Enhances Hepatitis B Virus Amplification

X Zhang, S Zhu, W Zhu, A Li, N Zhu - Viral Immunology, 2016 - liebertpub.com
Chronic hepatitis B virus (HBV) infection causes approximately one-third of all the cases of
liver cirrhosis and more than three-quarters of hepatocellular carcinoma (HCC) worldwide …

[引用][C] 乙型肝炎病毒polyA 形成与调节因素研究进展

关武祥, 杨东亮 - 中国病毒病杂志, 2011