Recent advances in the strategic incorporation of fluorine into new-generation taxoid anticancer agents

K Jayanetti, K Takemura, H Bendale, A Garg… - Journal of Fluorine …, 2023 - Elsevier
This account describes our recent progress on the strategic incorporation of fluorine and
organofluorine moieties into new-generation taxoid anticancer agents for medicinal …

Stabilizing fluorine–π interactions

P Li, JM Maier, EC Vik, CJ Yehl, BE Dial… - Angewandte …, 2017 - Wiley Online Library
A series of N‐arylimide molecular balances were designed to study and measure fluorine–
aromatic (F–π) interactions. Fluorine substituents gave rise to increasingly more stabilizing …

Fluorine in a C− F Bond as the Key to Cage Formation

MG Holl, CR Pitts, T Lectka - Angewandte Chemie International …, 2018 - Wiley Online Library
Cage molecules have long been employed to trap reactive or transient species, as their rigid
nature allows them to enforce situations that otherwise would not persist. In this Minireview …

Non-covalent allosteric regulation of capsule catalysis

V Martí-Centelles, RL Spicer, PJ Lusby - Chemical Science, 2020 - pubs.rsc.org
Allosteric regulation is an essential biological process that allows enzymes to modulate their
active site properties by binding a control molecule at the protein exterior. Here we show the …

Enantioselective Alkylation of Glycine Imines Using a Cinchona-Functionalized Crown Ether-Strapped Calixarene Phase-Transfer Catalyst

A Malik, PR Sharma, RK Sharma - The Journal of Organic …, 2023 - ACS Publications
We report a class of quaternary ammonium Cinchona-functionalized crown ether-strapped
calix [4] arene phase-transfer catalysts for the efficient enantioselective α-alkylation of …

New Theoretical Insight into Fluorination and Fluorine–Fluorine Interactions as a Driving Force in Crystal Structures

GV Janjić, ST Jelić, NP Trišović… - Crystal Growth & …, 2020 - ACS Publications
Fluorination of compounds causes an increase in the proton-donating ability and a decrease
in the proton-accepting capacity of groups in their vicinity. The formation of F··· F interactions …

Kinetically controlled synthesis of rotaxane geometric isomers

DR McCarthy, K Xu, ME Schenkelberg… - Chemical …, 2024 - pubs.rsc.org
Geometric isomerism in mechanically interlocked systems—which arises when the axle of a
mechanically interlocked molecule is oriented, and the macrocyclic component is facially …

Synthesis of benzylidenemalononitrile by Knoevenagel condensation through monodisperse carbon nanotube-based NiCu nanohybrids

N Zengin, H Burhan, A Şavk, H Göksu, F Şen - Scientific Reports, 2020 - nature.com
Monodisperse nickel/copper nanohybrids (NiCu@ MWCNT) based on multi-walled carbon
nanotubes (MWCNT) were prepared for the Knoevenagel condensation of aryl and aliphatic …

Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction

MS Islam, SL Junod, S Zhang, ZY Buuh, Y Guan… - Nature …, 2022 - nature.com
We report the discovery of a facile peptide macrocyclization and stapling strategy based on
a fluorine thiol displacement reaction (FTDR), which renders a class of peptide analogues …

Through‐Space, Lone‐Pair Promoted Aromatic Substitution: A Relay Mechanism Can Beat Out Direct Activation

M Kazim, Z Feng, S Vemulapalli… - … A European Journal, 2023 - Wiley Online Library
We report a detailed experimental and theoretical analysis of through‐space arene
activation with halogens, tetrazoles and achiral esters and amides. Contrary to previously …