Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …

Fluorine, often called as “a small atom with a big ego”, 1 lies in the second row and the 17th
column in the periodic table of the chemical elements. This unique position in the periodic …

The inner mitochondrial membrane (IMM) generates power to drive cell function, and its
dynamics control mitochondrial health and cellular homeostasis. Here, we describe the cell …

Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …