The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

Epithelial-to-mesenchymal transition (EMT) regulates tumour initiation, progression,
metastasis and resistance to anti-cancer therapy,,,,,–. Although great progress has been …

Drug resistance and cancer relapse represent significant therapeutic challenges after
chemotherapy or immunotherapy, and a major limiting factor for long-term cancer survival …

Patient-derived xenografts (PDX) are an increasingly valuable tool in oncology, providing
biologically faithful models of many different cancer types, and potential platforms for the …

Neural invasion (NI) is a vital pathological characteristic of gastric cancer (GC), which
correlates with tumor recurrence and a worse prognosis. Long noncoding RNAs (lncRNAs) …

Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients
and therefore must adapt their metabolism to ensure proliferation. In some physiological …

Cell invasion through the basement membrane (BM) occurs during normal embryonic
development and is a fundamental feature of cancer metastasis. The underlying cellular and …

The formation of vascular niche is pivotal during the early stage of peripheral nerve
regeneration. Nevertheless, the mechanisms of vascular niche in the regulation of …

Though critical to normal development and cancer metastasis, how cells traverse basement
membranes is poorly understood. A central impediment has been the challenge of …