The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
The lysosome as a cellular centre for signalling, metabolism and quality control
RE Lawrence, R Zoncu - Nature cell biology, 2019 - nature.com
Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …
Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
T Takahara, Y Amemiya, R Sugiyama, M Maki… - Journal of Biomedical …, 2020 - Springer
The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …
The structure of the nuclear pore complex (an update)
The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
The lysosome as a regulatory hub
The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …
discoveries have challenged this simple view and have established a central role of the …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Regulation of mTORC1 by amino acids
L Bar-Peled, DM Sabatini - Trends in cell biology, 2014 - cell.com
The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular
and organismal growth, and hyperactivation of this pathway is implicated in the …
and organismal growth, and hyperactivation of this pathway is implicated in the …
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
The mTOR complex 1 (mTORC1) pathway promotes cell growth in response to many cues,
including amino acids, which act through the Rag guanosine triphosphatases (GTPases) to …
including amino acids, which act through the Rag guanosine triphosphatases (GTPases) to …
Structure of the nutrient-sensing hub GATOR2
Mechanistic target of rapamycin complex 1 (mTORC1) controls growth by regulating
anabolic and catabolic processes in response to environmental cues, including nutrients …
anabolic and catabolic processes in response to environmental cues, including nutrients …
The lysosome as a command-and-control center for cellular metabolism
Lysosomes are membrane-bound organelles found in every eukaryotic cell. They are widely
known as terminal catabolic stations that rid cells of waste products and scavenge metabolic …
known as terminal catabolic stations that rid cells of waste products and scavenge metabolic …