Scaffolding strategies for tissue engineering and regenerative medicine applications
During the past two decades, tissue engineering and the regenerative medicine field have
invested in the regeneration and reconstruction of pathologically altered tissues, such as …
invested in the regeneration and reconstruction of pathologically altered tissues, such as …
3D bioprinting: current status and trends—a guide to the literature and industrial practice
The multidisciplinary research field of bioprinting combines additive manufacturing, biology
and material sciences to create bioconstructs with three-dimensional architectures …
and material sciences to create bioconstructs with three-dimensional architectures …
Personalised organs-on-chips: functional testing for precision medicine
Organs-on-chips are microfluidic systems with controlled, dynamic microenvironments in
which cultured cells exhibit functions that emulate organ-level physiology. They can in …
which cultured cells exhibit functions that emulate organ-level physiology. They can in …
Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies
P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems
Current practices in drug development have led to therapeutic compounds being approved
for widespread use in humans, only to be later withdrawn due to unanticipated toxicity …
for widespread use in humans, only to be later withdrawn due to unanticipated toxicity …
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
Pharmaceutical applications of 3D printing
Abstract Although 3D printing (3DP) has long been an integral part of industries such as
aviation and automotive, its use in healthcare, especially the pharmaceutical industry, is …
aviation and automotive, its use in healthcare, especially the pharmaceutical industry, is …
Immersion bioprinting of tumor organoids in multi-well plates for increasing chemotherapy screening throughput
E Maloney, C Clark, H Sivakumar, KM Yoo, J Aleman… - Micromachines, 2020 - mdpi.com
The current drug development pipeline takes approximately fifteen years and $2.6 billion to
get a new drug to market. Typically, drugs are tested on two-dimensional (2D) cell cultures …
get a new drug to market. Typically, drugs are tested on two-dimensional (2D) cell cultures …
Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform
Current drug development techniques are expensive and inefficient, partially due to the use
of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity …
of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity …
3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications
A Mazzocchi, S Soker, A Skardal - Applied Physics Reviews, 2019 - pubs.aip.org
High-throughput technologies have become essential in many fields of pharmaceutical and
biological development and production. Such technologies were initially developed with …
biological development and production. Such technologies were initially developed with …