Purpose The aim of this paper is to provide an overview of the most investigated optical
diagnostic techniques: optical coherence tomography, fluorescence spectrometry …

Clinical workflows for the non-invasive detection and characterization of disease states
could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities …

Effectiveness of surgery as a cancer treatment is reduced when all cancer cells are not
detected during surgery, leading to recurrences that negatively impact survival. To maximize …

The goal of this study was to determine the diagnostic capability of a multimodal spectral
diagnosis (SD) for in vivo noninvasive disease diagnosis of melanoma and nonmelanoma …

Activatable photoacoustic probes efficiently combine the high spatial resolution and
penetration depth of ultrasound with the high optical contrast and versatility of molecular …

Background Early accurate detection of all skin cancer types is essential to guide
appropriate management and to improve morbidity and survival. Melanoma and cutaneous …

Medical devices face many hurdles before they enter routine clinical practice to address
unmet clinical needs. This is also the case for biomedical optical spectroscopy and imaging …

Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown
limited efficacy in pigmented melanoma, mainly due to the poor penetration of light in this …

Determining the optical polarization properties of a skin lesion is a proposed method to
differentiate melanoma from other skin lesions. We developed an in vivo Stokes polarimetry …

Light scattering has become a common biomedical research tool, enabling diagnostic
sensitivity to myriad tissue alterations associated with disease. Light–tissue interactions are …