Nuclear pore complexes and regulation of gene expression

M Raices, MA D'Angelo - Current opinion in cell biology, 2017 - Elsevier
Highlights•Nuclear pore complexes and nucleoporins have many transport-independent
functions.•Nuclear pore complexes play key roles in gene expression regulation.•In yeast …

The nuclear pore complex in cell type-specific chromatin structure and gene regulation

J Sun, Y Shi, E Yildirim - Trends in genetics, 2019 - cell.com
Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key
cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC …

Heat shock factor 1 drives intergenic association of its target gene loci upon heat shock

S Chowdhary, AS Kainth, D Pincus, DS Gross - Cell reports, 2019 - cell.com
Transcriptional induction of heat shock protein (HSP) genes is accompanied by dynamic
changes in their 3D structure and spatial organization, yet the molecular basis for these …

DNA methylation-based high-resolution mapping of long-distance chromosomal interactions in nucleosome-depleted regions

Y Li, J Lee, L Bai - Nature Communications, 2024 - nature.com
Abstract 3C-based methods have significantly advanced our understanding of 3D genome
organization. However, it remains a formidable task to precisely capture long-range …

Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

J Lee, L Simpson, Y Li, S Becker, F Zou, X Zhang, L Bai - Elife, 2024 - elifesciences.org
Some transcription factors (TFs) can form liquid–liquid phase separated (LLPS)
condensates. However, the functions of these TF condensates in 3-Dimentional (3D) …

The nuclear pore complex and the genome: organizing and regulatory principles

P Pascual-Garcia, M Capelson - Current opinion in genetics & …, 2021 - Elsevier
The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein
complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …

The dynamic three-dimensional organization of the diploid yeast genome

S Kim, I Liachko, DG Brickner, K Cook, WS Noble… - Elife, 2017 - elifesciences.org
The budding yeast Saccharomyces cerevisiae is a long-standing model for the three-
dimensional organization of eukaryotic genomes. However, even in this well-studied model …

The role of transcription factors and nuclear pore proteins in controlling the spatial organization of the yeast genome

DG Brickner, C Randise-Hinchliff, ML Corbin… - Developmental Cell, 2019 - cell.com
Loss of nuclear pore complex (NPC) proteins, transcription factors (TFs), histone
modification enzymes, Mediator, and factors involved in mRNA export disrupts the physical …

Nuclear pores in genome architecture and enhancer function

P Pascual-Garcia, M Capelson - Current opinion in cell biology, 2019 - Elsevier
Nuclear genome architecture relies on interactions between the genome and various
nuclear scaffolds. One such a nuclear scaffold is the nuclear pore complex (NPC), which in …

[HTML][HTML] Mechanism of long-range chromosome motion triggered by gene activation

A Wang, JA Kolhe, N Gioacchini, I Baade, WM Brieher… - Developmental cell, 2020 - cell.com
Movement of chromosome sites within interphase cells is critical for numerous pathways
including RNA transcription and genome organization. Yet, a mechanism for reorganizing …