J Sun, Y Shi, E Yildirim - Trends in genetics, 2019 - cell.com
Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC …
Transcriptional induction of heat shock protein (HSP) genes is accompanied by dynamic changes in their 3D structure and spatial organization, yet the molecular basis for these …
Y Li, J Lee, L Bai - Nature Communications, 2024 - nature.com
Abstract 3C-based methods have significantly advanced our understanding of 3D genome organization. However, it remains a formidable task to precisely capture long-range …
J Lee, L Simpson, Y Li, S Becker, F Zou, X Zhang, L Bai - Elife, 2024 - elifesciences.org
Some transcription factors (TFs) can form liquid–liquid phase separated (LLPS) condensates. However, the functions of these TF condensates in 3-Dimentional (3D) …
The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …
The budding yeast Saccharomyces cerevisiae is a long-standing model for the three- dimensional organization of eukaryotic genomes. However, even in this well-studied model …
DG Brickner, C Randise-Hinchliff, ML Corbin… - Developmental Cell, 2019 - cell.com
Loss of nuclear pore complex (NPC) proteins, transcription factors (TFs), histone modification enzymes, Mediator, and factors involved in mRNA export disrupts the physical …
Nuclear genome architecture relies on interactions between the genome and various nuclear scaffolds. One such a nuclear scaffold is the nuclear pore complex (NPC), which in …
A Wang, JA Kolhe, N Gioacchini, I Baade, WM Brieher… - Developmental cell, 2020 - cell.com
Movement of chromosome sites within interphase cells is critical for numerous pathways including RNA transcription and genome organization. Yet, a mechanism for reorganizing …