Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease

LZ Kong, N Chandimali, YH Han, DH Lee… - International journal of …, 2019 - mdpi.com
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to
alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis …

Immunomodulatory effects of flavonoids: possible induction of T CD4+ regulatory cells through suppression of mTOR pathway signaling activity

A Hosseinzade, O Sadeghi… - Frontiers in …, 2019 - frontiersin.org
The increasing rate of autoimmune disorders and cancer in recent years has been a
controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among …

The potential and action mechanism of polyphenols in the treatment of liver diseases

S Li, HY Tan, N Wang, F Cheung… - … medicine and cellular …, 2018 - Wiley Online Library
Liver disease, involving a wide range of liver pathologies from fatty liver, hepatitis, and
fibrosis to cirrhosis and hepatocellular carcinoma, is a serious health problem worldwide. In …

Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication

S Jin, Q Cao, F Yang, H Zhu, S Xu, Q Chen, Z Wang… - Nature …, 2021 - nature.com
Alcohol is among the most widely used psychoactive substances worldwide. Ethanol
metabolites such as acetate, thought to be primarily the result of ethanol breakdown by …

Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies

AF Naeimi, M Alizadeh - Trends in food science & technology, 2017 - Elsevier
Background The overproduction of reactive oxygen species (ROS) by oxidative damage of
the cellular ingredients has a substantial role in the development of many diseases, such as …

Daucosterol Alleviates Alcohol− Induced Hepatic Injury and Inflammation through P38/NF− κB/NLRP3 Inflammasome Pathway

F Zhang, M Wang, Y Zha, J Zhou, J Han, S Zhang - Nutrients, 2023 - mdpi.com
Alcoholic liver disease (ALD) is caused by chronic excessive alcohol consumption, which
leads to inflammation, oxidative stress, lipid accumulation, liver fibrosis/cirrhosis, and even …

Natural products for prevention and treatment of chemical‐induced liver injuries

X Meng, Y Li, S Li, RY Gan, HB Li - Comprehensive Reviews in …, 2018 - Wiley Online Library
Chemicals (such as alcohol, drugs, and pollutants) may cause liver injuries, which could
consequently develop into fatty liver, hepatitis, fibrosis, cirrhosis, and liver failure, or even …

Flavonoids-mediated SIRT1 signaling activation in hepatic disorders

AM Sayed, EHM Hassanein, SH Salem, OE Hussein… - Life sciences, 2020 - Elsevier
The prevalence of various hepatic diseases increases dramatically worldwide and regarded
as a serious health problem. Sirtuins are one of the main strategic controllers of different …

[HTML][HTML] Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine

P Mehta, A Pawar, K Mahadik, C Bothiraja - Biomedicine & …, 2018 - Elsevier
Fisetin (FIS), a bioactive flavonol found in the smoke tree (Cotinus coggygria), vegetables,
fruits and nuts. It exhibits various therapeutic activities such as anti-oxidant, anti …

Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway

L Zhang, H Wang, Y Zhou, Y Zhu, M Fei - Neurochemistry international, 2018 - Elsevier
Fisetin, a natural flavonoid, has neuroprotection properties in many brain injury models.
However, its role in traumatic brain injury (TBI) has not been fully explained. In the present …