Biomarkers in colorectal cancer: current research and future prospects

OO Ogunwobi, F Mahmood, A Akingboye - International journal of …, 2020 - mdpi.com
Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in
detection and management through surgery, chemotherapy, radiotherapy, and …

Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance

L Yuan, ZY Xu, SM Ruan, S Mo, JJ Qin, XD Cheng - Molecular cancer, 2020 - Springer
Gastric cancer is a deadly disease and remains the third leading cause of cancer-related
death worldwide. The 5-year overall survival rate of patients with early-stage localized …

LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53

J Lu, F Xu, H Lu - Life sciences, 2020 - Elsevier
Aim The study aims to investigate the roles of LncRNA and miRNA in ferroptosis in brain
ischemia/reperfusion (I/R) in vivo and in vitro. Materials and methods qPCR assay was used …

The potential relevance of long non-coding RNAs in colorectal cancer pathogenesis and treatment: a review focus on signaling pathways

AS Doghish, MB Zaki, MG Eldeib, AF Radwan… - … -Research and Practice, 2024 - Elsevier
Colorectal cancer (CRC) is one of the most frequent cancers in incidence and mortality.
Despite advances in cancer biology, molecular genetics, and targeted treatments, CRC …

lncRNA PVT1: a novel oncogene in multiple cancers

R Li, X Wang, C Zhu, K Wang - Cellular & molecular biology letters, 2022 - Springer
Long noncoding RNAs are involved in epigenetic gene modification, including binding to the
chromatin rearrangement complex in pre-transcriptional regulation and to gene promoters in …

Unraveling the ncRNA landscape that governs colorectal cancer: A roadmap to personalized therapeutics

NM Hamdy, MB Zaki, NI Rizk, NM Abdelmaksoud… - Life Sciences, 2024 - Elsevier
Colorectal cancer (CRC) being one of the most common malignancies, has a significant
death rate, especially when detected at an advanced stage. In most cases, the fundamental …

The PI3K/Akt/mTOR axis in colorectal cancer: oncogenic alterations, non‐coding RNAs, therapeutic opportunities, and the emerging role of nanoparticles

MJ Sanaei… - Journal of Cellular …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is one of the deadliest human malignancies worldwide. Several
molecular pathways have been demonstrated to be involved in the initiation and …

[HTML][HTML] Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions

SM Fortier, LR Penke, D King, TX Pham, G Ligresti… - JCI insight, 2021 - ncbi.nlm.nih.gov
Myofibroblasts are the major cellular source of collagen, and their accumulation—via
differentiation from fibroblasts and resistance to apoptosis—is a hallmark of tissue fibrosis …

lncRNA PVT1 promotes tumorigenesis of colorectal cancer by stabilizing miR-16-5p and interacting with the VEGFA/VEGFR1/AKT axis

H Wu, M Wei, X Jiang, J Tan, W Xu, X Fan… - … Therapy-Nucleic Acids, 2020 - cell.com
Recently, the long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1)
was reported to be involved in the pathogenesis of several cancers, including human …

Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease

D Traversa, G Simonetti, D Tolomeo, G Visci… - British journal of …, 2022 - nature.com
The plasmacytoma variant translocation 1 (PVT1) is a long non-coding RNA gene involved
in human disease, mainly in cancer onset/progression. Although widely analysed, its …