Clostridium difficile disease has recently increased to become a dominant nosocomial
pathogen in North America and Europe, although little is known about what has driven this …

Broadly neutralizing antibodies targeting the stalk region of influenza A virus (IAV)
hemagglutinin (HA) are effective in blocking virus infection both in vitro and in vivo. The …

The chemo-enzymatic and enzymatic synthesis of heparan sulfate and heparin are
considered as an attractive alternative to the extraction of heparin from animal tissues …

Abstract The matrix protein 1 (M1) of influenza A virus (IAV) exists as a three-dimensional
oligomeric structure in mature virions with high sequence conservation across different IAV …

In the catalytic mechanism of hydrolytic aldehyde dehydrogenases (ALDHs) the role of
Glu268 (mature human ALDH2 numbering) as a general base is of major relevance. Since …

Background The sequence logo is a graphical representation of a set of aligned sequences,
commonly used to depict conservation of amino acid or nucleotide sequences. Although it …

Abstract Background The 2013 BioVis Contest provided an opportunity to evaluate different
paradigms for visualizing protein multiple sequence alignments. Such data sets are …

Antiviral drug resistance is a major problem in the treatment of viral infections, including
influenza and hepatitis C virus (HCV). Influenza neuraminidase (NA) is a viral sialidase on …

Neste trabalho, foram abordados o problema de alinhamento de sequências menores,
correspon-dentes a genes ou proteínas individuais, como para sequências grandes do …

The advents of technologies have led to tremendous increases in the diversity and size of
the available data. In the field of medicine, the advancements in medical imaging …