Regulation of mTORC1 by PI3K signaling
CC Dibble, LC Cantley - Trends in cell biology, 2015 - cell.com
The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
Key factors in mTOR regulation
X Bai, Y Jiang - Cellular and molecular life sciences, 2010 - Springer
Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that controls a
wide range of growth-related cellular processes. In the past several years, many factors …
wide range of growth-related cellular processes. In the past several years, many factors …
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
H Yang, X Jiang, B Li, HJ Yang, M Miller, A Yang… - Nature, 2017 - nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and
metabolism in response to nutrients, energy levels, and growth factors. It contains the …
metabolism in response to nutrients, energy levels, and growth factors. It contains the …
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
Abstract Lipidated Rho and Rab GTP-binding proteins are transported between membranes
in complex with solubilizing factors called'guanine nucleotide dissociation inhibitors'(GDIs) …
in complex with solubilizing factors called'guanine nucleotide dissociation inhibitors'(GDIs) …
Structural insights into TSC complex assembly and GAP activity on Rheb
Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by
controlling the activity of mTORC1. TSC complex functions as a GTPase-activating protein …
controlling the activity of mTORC1. TSC complex functions as a GTPase-activating protein …
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein
T Sato, A Nakashima, L Guo, F Tamanoi - Journal of Biological Chemistry, 2009 - ASBMB
Rheb G-protein plays critical roles in the TSC/Rheb/mTOR signaling pathway by activating
mTORC1. The activation of mTORC1 by Rheb can be faithfully reproduced in vitro by using …
mTORC1. The activation of mTORC1 by Rheb can be faithfully reproduced in vitro by using …
Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb
The mammalian target of rapamycin (mTOR) interacts with raptor to form the protein complex
mTORC1 (mTOR complex 1), which plays a central role in the regulation of cell growth in …
mTORC1 (mTOR complex 1), which plays a central role in the regulation of cell growth in …
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
M Zheng, YH Wang, XN Wu, SQ Wu, BJ Lu… - Nature cell …, 2011 - nature.com
Cell growth can be suppressed by stressful environments, but the role of stress pathways in
this process is largely unknown. Here we show that a cascade of p38β mitogen-activated …
this process is largely unknown. Here we show that a cascade of p38β mitogen-activated …
[HTML][HTML] A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
SJ Mahoney, S Narayan, L Molz, LA Berstler… - Nature …, 2018 - nature.com
The small G-protein Rheb activates the mechanistic target of rapamycin complex 1
(mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular …
(mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular …