Small RNAs regulate a wide variety of biological processes by repressing the expression of
target genes at the transcriptional and post-transcriptional levels. To achieve these …

Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles. Here, we
describe a regulatory network centered on four ncRNAs—a long ncRNA, a circular RNA …

MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …

The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome
editing, possesses two distinct nuclease activities: endoribonuclease activity for processing …

The global diversity of fungi has been estimated between 2 to 11 million species, of which
only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they …

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

To identify endogenous miRNA-target sites, we isolated AGO-bound RNAs from
Caenorhabditis elegans by individual-nucleotide resolution crosslinking …

Argonaute proteins (Agos) use small 15–30 nucleotide-long guides to bind and/or cleave
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …