Quinolone antimicrobials are widely used in clinical medicine and are the only current class
of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase …

The emergence and spread of mobile antibiotic resistance genes (ARGs) in pathogens have
become a serious threat to global health. Still little is known about where ARGs gain mobility …

Allogeneous selection occurs when an antibiotic selects for resistance to more advanced
members of the same family. The mechanisms of allogenous selection are (a) collateral …

Since the introduction of antibiotics as therapeutic agents, many bacterial pathogens have
developed resistance to antibiotics. Mobile resistance genes, acquired through horizontal …

Objectives: Citrobacter freundii is a frequent cause of nosocomial infections and a known
cause of diarrheal infections, and has increasingly become multidrug resistant (MDR). In this …

ABSTRACT qnrE1, found in a clinical Klebsiella pneumoniae isolate, was undetectable by
PCR assays used for the six qnr families. qnrE1 was located on a conjugative plasmid (ca …

Fluoroquinolones are used to treat serious bacterial infections, including those caused by
Escherichia coli and Salmonella enterica. The emergence of plasmid-mediated quinolone …

House mice (Mus musculus) thrive in large urban centers worldwide. Nonetheless, little is
known about the role that they may play in contributing to environmental contamination with …

Antimicrobial usage in aquaculture selects for antimicrobial-resistant microorganisms in the
marine environment. The relevance of this selection to terrestrial animal and human health …

Background The mcr-1 gene is a transferable resistance determinant against colistin, a last-
resort antimicrobial for infections caused by multi-resistant Gram-negatives. Aim To study …