The ongoing COVID-19 pandemic has highlighted the need to incorporate pathogen
genomics for enhanced disease surveillance and outbreak management in Africa. The …

The use of NGS technologies on HIV DR testing will allow unprecedented insights into
genomic structures of virus populations that may be of immediate relevance to both clinical …

Contemporary antiretroviral therapy (ART) regimens have high barriers to the development
of drug resistance. However, resistance to earlier antiretrovirals and uncommon cases of …

Background Next-generation sequencing (NGS) is gradually replacing Sanger sequencing
(SS) as the primary method for HIV genotypic resistance testing. However, there are limited …

HIV drug resistance is a major global challenge to successful and sustainable antiretroviral
therapy. Next-generation sequencing (NGS)-based HIV drug resistance (HIVDR) assays …

The greatest HIV-1 genetic diversity is found in West/Central Africa due to the pandemic's
origins in this region, but this diversity remains understudied. We characterized HIV-1 …

Background: Next-generation sequencing (NGS) is gradually replacing Sanger sequencing
for HIV genotypic drug resistance testing (GRT). This work evaluated the concordance …

Background: There are an increasing number of articles focused on the prevalence and
clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing …

Background The association between low-frequency human immunodeficiency virus type 1
(HIV-1) drug resistance mutations (DRMs) and treatment failure (TF) is controversial. We …

There has been no systematic review of the prevalence of transmitted integrase strand
transfer inhibitor (INSTI) resistance. We systematically searched the English-language …